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What is the most likely pathophysiology for this patient’s presentation?

A 57-year-old male presents for a telemedicine video visit for evaluation of upper lip swelling. He denies any swelling of the tongue or throat, change in voice, trauma, or itchiness. He also denies any known insect bites, allergic exposures, or food or medication allergies. Review of the patient’s record reveals...

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What is the most likely pathophysiology for this patient’s presentation?