A Figure 1 podcast
A Figure 1 podcast

DDx: A Podcast About How Doctors Think

DDx is medical shorthand for differential diagnosis, and this is a podcast about how doctors think and learn on the job. It’s hosted by Dr. Raj Bhardwaj and is produced by Figure 1, the global knowledge-sharing platform for medicine.

Latest Episodes


The Importance of Genetic Screening

Genetic screening is vital for early diagnosis and management of genetic diseases. Dig into how it works, how it can help treatments reach patients sooner, and how it informs traditional treatments like physical therapy.


ALS, DMD and Adapting Treatment Mechanisms for Genetic Variations

Understand the different mechanisms by which gene therapy can potentially treat specific genetic diseases – such as amyotrophic lateral sclerosis, or ALS, and Duchenne muscular dystrophy, or DMD.


Gene Therapy in Action: Adeno-Associated Viral Vectors

Adeno-associated viral vectors, or AAVs, are the tiny shells of viruses and are the most common vessels for delivering gene-based therapies. Launch into the past, present, and future of these viral rocket ships.


The Future of Gene Therapy and Genetic Diseases

Peek into the future of gene therapy and its capacity to treat – maybe eliminate – genetic diseases like cancers and hemophilia. Plus, hear how gene therapy may be on the frontier of reversing the effects of aging.


How Does Gene Therapy Work? Correcting Disease-Causing Genetic Variations

While some genetic variations are positive, others can cause or contribute to disease. Learn how gene therapy replaces and repairs certain gene variants, and is changing the trajectory of genetic diseases.


A Brief History of Gene Therapy and the Discovery of DNA

Explore some of the major scientific findings – like discovering DNA – that set the stage for gene therapy, and its groundbreaking potential in the treatment of genetic diseases.


Take a deep dive into one of the most awe-inspiring medical innovations of our time: gene therapy. This season, we’ll explore the infinite universe inside the tiny molecules of our DNA, and look at medical technology with the potential to reshape our approach to treating many genetic diseases.

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The information shared in DDx is not intended nor implied to be a substitute for professional medical advice. It is provided for educational purposes only.

Catch up on season 2

In the first season of DDx, physicians share soThis season explores the complex cases faced by dermatologists — from the psychosocial comorbidities of skin disease to the potentially fatal complications of a rash.

Catch up on season 3

Meet the doctors searching for the zebra among a herd of horses. Explore the challenges in distinguishing rare diseases from common ones, and how to recognize them when the stakes are life and death.

About DDx

DDx is medical shorthand for differential diagnosis, a system of analysis designed to identify the root cause of complex patient symptoms. This is a medical podcast about how doctors think and learn on the job — exploring complex areas of medicine and difficult medical cases. The show is hosted by Dr. Raj Bhardwaj and produced by Figure 1.